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Which Injection Works Better for Thumb Arthritis Pain?

April 17, 2026 7 min read
Which Injection Works Better for Thumb Arthritis Pain?

If you have pain at the base of your thumb, you may have heard about two different types of injections that can help. This article explains what scientists found when they compared these two treatments.

Here are the main points you will learn:

  • What two injections were tested for thumb arthritis
  • How well each injection worked over time
  • Which one lasted longer

Key Findings at a Glance

  • Research shows that both hyaluronic acid and steroid injections reduce thumb arthritis pain
  • Steroid injections work faster, giving relief within 2 to 3 weeks
  • Hyaluronic acid injections work more slowly but last longer, with best results at 6 months
  • According to this study, 88% of patients treated with hyaluronic acid had pain improvement after 26 weeks
  • Both treatments were safe with no serious side effects

What Is Thumb Arthritis?

Thumb arthritis happens at the base of your thumb. The medical name for this is rhizarthrosis. The joint where your thumb meets your wrist can wear down over time. This causes pain, swelling, and makes it hard to grip things.

What is the CMC joint? CMC stands for carpometacarpal. This is the joint at the very base of your thumb where it connects to your wrist. When this joint gets arthritis, it is called rhizarthrosis.

Many people with this condition look for treatments that do not involve surgery. Injections are one option that doctors often suggest.

What Did This Study Look At?

According to research published in Osteoarthritis and Cartilage, scientists wanted to compare two different injections for thumb arthritis. They watched 56 patients for 26 weeks. That is about 6 months.

Half of the patients got one type of injection. The other half got a different type. The doctors carefully measured how much pain each person felt. They also checked how well the thumb could move and how strong the grip was.

Let us look closer at what these two injections are.

What Are These Two Types of Injections?

The first injection is called sodium hyaluronate. The brand name used in this study was Ostenil mini. You can think of this as a thick gel that helps cushion your joint. It is like adding oil to a squeaky door hinge.

What is hyaluronic acid? This is a natural substance that is already in your joints. It acts like a cushion and helps your joints move smoothly. When you have arthritis, your body makes less of it. An injection adds more back in.

The second injection is called triamcinolone acetonide. The brand name was Volon A10. This is a type of steroid medicine. It works by calming down swelling and pain in the joint.

What is a corticoid or steroid injection? This is a medicine that reduces swelling and pain very quickly. It is like a fire extinguisher for inflammation in your joint.

Each person got three injections over a short period of time. Then the doctors watched what happened.

How Fast Did Each Injection Work?

Here is where it gets interesting. The two injections worked at very different speeds.

Research shows that the steroid injection worked much faster. Patients felt the most pain relief at 2 to 3 weeks after their first injection. The steroid was better than the hyaluronic acid during those early weeks.

The hyaluronic acid injection worked more slowly. It took longer to feel the full benefit. But something important happened as time went on.

Which Injection Lasted Longer?

You may be wondering why this matters. The answer is about how long the relief lasts.

According to this study, the hyaluronic acid showed its best results at week 26. That is 6 months after the first injection. At that point, the hyaluronic acid was slightly better than the steroid.

The study found that hyaluronic acid had a superior long lasting effect compared to the steroid injection.

Let us look at the numbers more closely:

Time Point Steroid Injection Hyaluronic Acid
Weeks 2 to 3 Works better Still building up
Week 26 Effect wearing off Works better

What About Grip Strength?

The study also looked at how well people could pinch things with their thumb. This is called lateral pinch power. Think about pinching a key to turn it in a lock.

After 26 weeks, the people who got hyaluronic acid had significantly better pinch strength. This means they could use their thumb better for everyday tasks.

How Many People Felt Better?

The numbers are encouraging for both treatments. Studies indicate that 88% of patients treated with hyaluronic acid said their pain was better after 26 weeks. For the steroid group, 79% said their pain improved.

Both numbers are good. But the hyaluronic acid had a slightly higher success rate.

Were There Any Side Effects?

This is an important question. You want to know if these treatments are safe.

According to medical evidence from this study, both treatments were well tolerated. That means most people did not have problems with them. No serious side effects happened that were caused by the injections.

This is good news. It means these treatments are generally safe for most people.

About This Site

This website simplifies medical science for people with thumb pain and rhizarthrosis. We use only published scientific articles to give you clear, honest information. You do not need a medical degree to understand your options. We invite you to explore more articles to learn about your condition and what treatments might help you.

Common Questions

How many injections will I need?

According to this study, patients received three injections. The doctors gave all three injections over a short period at the beginning of treatment. Then they watched the results for 6 months.

Which injection should I choose?

Research shows that if you want fast relief, the steroid injection works within 2 to 3 weeks. If you want relief that lasts longer, hyaluronic acid may be a better choice because it showed superior results at 6 months. Talk with your doctor about what matters most to you.

Will these injections cure my thumb arthritis?

No. These injections help manage pain and improve how your thumb works. They do not cure arthritis. But they can make your daily life easier and less painful.

Are these injections safe?

Studies indicate that both types of injections were well tolerated in this research. No serious side effects occurred that were caused by the injections. Always talk with your doctor about your personal health situation.

What This Means for You

If you have thumb arthritis, you now know there are two good injection options. Each one works differently.

Steroid injections give you faster relief. You might feel better within a few weeks. This can be helpful if you need quick pain relief.

Hyaluronic acid injections work more slowly. But the benefits last longer. After 6 months, research shows this treatment may work better than steroids. Your grip strength may also improve more.

The next step is to talk with your doctor. Share what you learned here. Ask which treatment might be right for your situation. Your doctor knows your medical history and can guide you to the best choice.

You deserve to have less pain and better thumb function. These treatments may help you get there.

Important Note

This article shares information from a scientific study. It is not medical advice. Every person is different. What works for one person may not work for another. Always talk with your doctor before starting any new treatment. Your doctor can look at your specific situation and help you make the best choice for your health.

Study Source

This article is based on research by Fuchs, S., Monikes, R., Wohlmeiner, A., and Heyse, T. (2006). The study was published in Osteoarthritis and Cartilage.

https://doi.org/10.1016/j.joca.2005.07.016

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Medical Disclaimer: This resource is patient-authored and based on peer-reviewed research. It is not a substitute for professional medical advice. Always consult your healthcare provider before making any treatment decisions.
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