Conservative Treatment

Are Hyaluronic Acid Injections for Thumb Arthritis Painful?

May 30, 2026 6 min read
Are Hyaluronic Acid Injections for Thumb Arthritis Painful?

If you have thumb arthritis, you might have heard about hyaluronic acid injections as a treatment option. Many people wonder how much these injections hurt and if they are really worth it. This article explains what a recent study found about pain during these treatments.

Here are three important things you will learn:

  • How painful hyaluronic acid injections are for thumb arthritis
  • Whether using an X-ray machine during the injection makes a difference
  • Why some patients still choose this treatment even though it can hurt

Key Findings at a Glance

  • Research shows that hyaluronic acid injections for thumb arthritis are tolerable but not painless
  • According to this study, patients who received injections with X-ray guidance felt much more pain than those without
  • Studies indicate that three weekly injections can help patients with advanced thumb arthritis who want to avoid surgery
  • The treatment is considered a viable option for stages 3 and 4 thumb arthritis

What Did This Study Look At?

This study wanted to find out how much pain people feel when they get hyaluronic acid injections for thumb arthritis. It also wanted to know if people could tolerate the treatment well.

What is thumb arthritis? Thumb arthritis is also called rhizarthrosis or trapeziometacarpal osteoarthritis. It happens when the joint at the base of your thumb wears down and becomes painful. This mostly affects women who are middle aged.

The researchers looked at patients with advanced thumb arthritis. These were people with stage 3 or stage 4 disease. These stages mean the arthritis is quite serious.

Most people with this kind of thumb arthritis can get better without surgery. That is good news. This study focused on one treatment option called viscosupplementation.

What is viscosupplementation? This is a treatment where doctors inject a thick fluid called hyaluronic acid into a painful joint. The fluid acts like a cushion and helps the joint move more smoothly.

How Did The Study Work?

The researchers divided 16 patients into two groups. Each group had eight patients. Both groups had stage 3 or 4 thumb arthritis.

Each patient received three injections over three weeks. They got one injection per week. Each injection contained 0.3 cubic centimeters of sodium hyaluronate. That is a type of hyaluronic acid.

Here is where it gets interesting. The two groups got their injections in different ways.

The Two Groups

Group How Injections Were Given
Group A With fluoroscopy control
Group B Without fluoroscopy control
What is fluoroscopy? Fluoroscopy is a type of X-ray that shows live moving images. Doctors use it to see exactly where the needle goes during an injection. It helps them make sure the medicine goes into the right spot.

The doctors measured how much pain each patient felt. They also asked patients how well they could tolerate the treatment. Then they compared the two groups to see which method worked better.

What Did Patients Say About Pain?

The results showed something surprising. All patients said the injections were tolerable. That means they could handle the treatment even though it was uncomfortable.

But patients also complained about pain and discomfort during the injections. So the treatment was not painless.

You may be wondering why this matters. The most important finding was about the difference between the two groups.

The Pain Difference Between Groups

According to this study, patients in group A felt much more pain than patients in group B. Remember, group A got their injections with fluoroscopy. Group B got their injections without the X-ray machine.

This surprised the researchers. They expected that using fluoroscopy would make the injections less painful because the needle would go in the right spot more easily.

But the opposite happened. The patients who had fluoroscopy felt more pain.

Why Does This Matter For You?

If you have advanced thumb arthritis and do not want surgery, this treatment might help you. Research shows that hyaluronic acid injections can work for stages 3 and 4 thumb arthritis.

But you should know what to expect. The injections will probably hurt. They are not painless. Most people can tolerate them, but you will feel discomfort.

Let us look closer at what the researchers recommend.

What Do The Researchers Recommend?

The researchers say that doctors should give these injections under fluoroscopy control. This seems confusing because fluoroscopy caused more pain in the study.

But the researchers still think fluoroscopy is important. It helps make sure the medicine goes exactly where it needs to go. That might make the treatment work better even if it hurts more during the injection.

About This Site: We simplify medical science to help you understand thumb pain and rhizarthrosis better. Every article on this site is based on published scientific research. We translate complex medical studies into plain language so you can make informed decisions about your health. Explore more articles to learn about different treatment options, causes, and ways to manage thumb arthritis.

Common Questions

How many injections do I need for thumb arthritis?

According to this study, the treatment involves three injections given once per week over three weeks. This is called one cycle of treatment.

Can I use hyaluronic acid injections instead of surgery?

Research shows that viscosupplementation is a viable treatment option for patients with stages 3 and 4 thumb arthritis who do not want to be operated on. It offers an alternative to surgery.

Will the injections hurt a lot?

Studies indicate that patients complain of pain and discomfort during the injections. The treatment is tolerable but not painless. The amount of pain may depend on whether your doctor uses fluoroscopy during the injection.

Who gets thumb arthritis most often?

According to medical evidence, trapeziometacarpal osteoarthritis predominantly affects middle aged women. However, other people can get it too.

What You Should Remember

Hyaluronic acid injections can help people with advanced thumb arthritis. The treatment involves three weekly injections. Most people can tolerate the procedure even though it causes pain and discomfort.

If you are considering this treatment, talk to your doctor about what to expect. Ask whether they will use fluoroscopy during the injections. This can help you prepare for the experience.

Remember that this treatment is an option when you want to avoid surgery. It may help reduce your thumb pain and improve how your joint works.

Important Information

This article explains research findings about thumb arthritis treatment. It is for educational purposes only. It is not medical advice. Always talk to your doctor before starting any new treatment. Your doctor knows your specific situation and can give you personalized advice about what treatment is right for you.

Study Source

This article is based on research by Karalezli, N., Ogun, T. C., Kartal, S., Saracgil, S. N., Yel, M., and Tuncay, I., published in Clinical Rheumatology in 2007.

https://doi.org/10.1007/s10067-006-0354-7

Compare every treatment option side by side before making any decisions.

Treatment Comparison

Research Updates

New Studies, Summarised for Patients

When a new peer-reviewed study on thumb arthritis is published — treatment, surgery, or recovery — I read it and send you the key findings in plain language.

No spam. Unsubscribe anytime.

Medical Disclaimer: This resource is patient-authored and based on peer-reviewed research. It is not a substitute for professional medical advice. Always consult your healthcare provider before making any treatment decisions.
Scroll to Top